Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used for postoperative pain
control. However, concerns regarding the potential deleterious effects of NSAIDs on bone …

Stress fractures are common injuries in athletes and military recruits. These injuries occur
more commonly in lower extremities than in upper extremities. Stress fractures should be …

The osteoblast/osteoclast and M1/M2 macrophage ratios play critical roles in delayed
fracture healing. Robust osteoblast differentiation and M2 macrophage polarization can …

Sports medicine physicians often treat athletes in pain with non-steroidal anti-inflammatory
drugs (NSAIDs). However, there is a lack of high-quality evidence to guide NSAID use. Their …

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are often avoided by
orthopaedic surgeons because of their possible influence on bone-healing. This belief …

Abstract Purpose of Review This paper describes recent advances in understanding the
mechanisms that drive fracture pain and how these findings are helping develop new …

STUDY OBJECTIVE: We compare the treatment of pain in children with arm fractures by
ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine …

The widely used non-steroidal anti-inflammatory drugs (NSAIDs) function mainly through
inhibition of cyclooxygenases 1 and 2 (Cox-1 and Cox-2). Unlike Cox-1, Cox-2 is considered …

Stress fractures are widely encountered in sport medicine and rheumatology. Stress
fractures result from abnormal and repetitive loading on normal bone that lead to …

Background: The analgesic efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) is well
established, and these agents often form an integral part of posttraumatic pain management …