The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …

Next‐generation sequencing allows the characterization of the adaptive immune receptor
repertoire (AIRR) in exquisite detail. These large‐scale AIRR‐seq data sets have rapidly …

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …

The small intestine contains CD4+ CD8αα+ double-positive intraepithelial lymphocytes (DP
IELs), which originate from intestinal CD4+ T cells through down-regulation of the …

B cells are important in the pathogenesis of many, and perhaps all, immune-mediated
diseases. Each B cell expresses a single B cell receptor (BCR), and the diverse range of …

IMGT®, the international ImMunoGeneTics information system®(http://www. imgt. org) is the
global reference in immunogenetics and immunoinformatics. By its creation in 1989 by …

Abstract IMGT/V-QUEST is the highly customized and integrated system for the standardized
analysis of the immunoglobulin (IG) and T cell receptor (TR) rearranged nucleotide …

Abstract IMGT/V-QUEST is the highly customized and integrated online IMGT® tool for the
standardized analysis of the immunoglobulin (IG) or antibody and T cell receptor (TR) …

IMGT®, the international ImMunoGeneTics information system®(http://www. imgt. org), was
created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGénétique Moléculaire LIGM …

We report here that in chronic lymphocytic leukemia (CLL), the propensity to generate clonal
B cells has been acquired already at the hematopoietic stem cell (HSC) stage. HSCs …