[PDF][PDF] Hepatotoxicity from immune checkpoint inhibitors: a systematic review and management recommendation

T Peeraphatdit, J Wang, MA Odenwald, S Hu… - …, 2020 - Wiley Online Library
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies targeting immune checkpoint
molecules. ICIs are an immunotherapy for the treatment of many advanced malignancies …

[HTML][HTML] Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C

S Tanwar, F Rhodes, A Srivastava… - World journal of …, 2020 - ncbi.nlm.nih.gov
At present chronic liver disease (CLD), the third commonest cause of premature death in the
United Kingdom is detected late, when interventions are ineffective, resulting in …

[HTML][HTML] Liver toxicity as a limiting factor to the increasing use of immune checkpoint inhibitors

E De Martin, JM Michot, O Rosmorduc, C Guettier… - JHEP Reports, 2020 - Elsevier
Immune checkpoint inhibitors (ICIs) improve clinical outcomes in patients suffering from
different types of cancer. Liver toxicity is one of the immune-related adverse events …

[HTML][HTML] Immune checkpoint inhibitor-related hepatotoxicity: A review

D Remash, DS Prince, C McKenzie… - World journal of …, 2021 - ncbi.nlm.nih.gov
The application of immune checkpoint inhibitors (ICI) in advanced cancer has been a major
development in the last decade. The indications for ICIs are constantly expanding into new …

Drug-induced liver injury: highlights and controversies in the recent literature

JW Clinton, S Kiparizoska, S Aggarwal, S Woo… - Drug safety, 2021 - Springer
Drug-induced liver injury (DILI) remains an important, yet challenging diagnosis for
physicians. Each year, additional drugs are implicated in DILI and this year was no different …

Immune-mediated hepatitis induced by immune checkpoint inhibitors: Current updates and future perspectives

Z Liu, Y Zhu, H Xie, Z Zou - Frontiers in Pharmacology, 2023 - frontiersin.org
In recent years, cancer immunotherapy has made remarkable achievements. Immune
checkpoint inhibitors (ICIs) have been used successfully in several types of cancer in the …

[HTML][HTML] Plasma exchange in patients with acute and acute-on-chronic liver failure: a systematic review

EXX Tan, MX Wang, J Pang, GH Lee - World journal of …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Acute liver failure (ALF) and acute-on-chronic liver (ACLF) carry high short-
term mortality rate, and may result from a wide variety of causes. Plasma exchange has …

Hepatotoxicity induced by immune checkpoint inhibitors: a comprehensive review including current and alternative management strategies

JJ Jennings, R Mandaliya, A Nakshabandi… - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Immune checkpoint inhibitors (ICIs) block cytotoxic T lymphocyte
antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1)/PD ligand 1 (PD-L1) …

Checkpoint inhibitor-induced liver injury: a novel form of liver disease emerging in the era of cancer immunotherapy

Y Zen, MM Yeh - Seminars in diagnostic pathology, 2019 - Elsevier
Liver injury triggered by immune checkpoint inhibitors has been increasingly seen in clinical
practice, and the incidence is likely to rise further in the next several years because of …

Retreatment with immune checkpoint inhibitors after a severe immune-related hepatitis: results from a prospective multicenter study

M Riveiro-Barciela, A Barreira-Díaz… - Clinical …, 2023 - Elsevier
Background & Aims Liver injury related to immunotherapy is a relatively frequent immune-
related adverse event that requires permanent discontinuation of immune checkpoint …