Epigenetic mechanisms in drug relapse
A growing body of evidence from the past 15 years implicates epigenetic mechanisms in the
behavioral effects of addictive drugs. The main focus of these studies has been epigenetic …
behavioral effects of addictive drugs. The main focus of these studies has been epigenetic …
The ubiquitin-proteasome system and learning-dependent synaptic plasticity–A 10 year update
Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition
The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A. Z and repress autophagy
X Li, Q Mei, Q Yu, M Wang, F He, D Xiao, H Liu… - Science …, 2023 - science.org
Autophagy is a critical process to maintain homeostasis, differentiation, and development.
How autophagy is tightly regulated by nutritional changes is poorly understood. Here, we …
How autophagy is tightly regulated by nutritional changes is poorly understood. Here, we …
[HTML][HTML] Histone H3 dopaminylation in nucleus accumbens, but not medial prefrontal cortex, contributes to cocaine-seeking following prolonged abstinence
AF Stewart, AE Lepack, SL Fulton, P Safovich… - Molecular and Cellular …, 2023 - Elsevier
Enduring patterns of epigenomic and transcriptional plasticity within the mesolimbic
dopamine system contribute importantly to persistent behavioral adaptations that …
dopamine system contribute importantly to persistent behavioral adaptations that …
Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence
Relapse vulnerability in substance use disorder is attributed to persistent cue-induced drug
seeking that intensifies (or “incubates”) during drug abstinence. Incubated cocaine seeking …
seeking that intensifies (or “incubates”) during drug abstinence. Incubated cocaine seeking …
Epigenetics of drug addiction
Substance use disorders (SUDs) are chronic brain diseases characterized by transitions
from recreational to compulsive drug use and aberrant drug craving that persists for months …
from recreational to compulsive drug use and aberrant drug craving that persists for months …
Disrupting astrocyte-neuron lactate transport prevents cocaine seeking after prolonged withdrawal
W Chen, Y Zhang, J Liang, Z Zhang, L Zhang… - Science …, 2023 - science.org
Energy supply, especially the transfer of lactate from astrocytes to neurons, is critical for
neuronal plasticity. However, its role in the incubation of cocaine craving remains largely …
neuronal plasticity. However, its role in the incubation of cocaine craving remains largely …
Trajectories of craving in the course of pharmacotherapy trials for methamphetamine use disorder
Aims The aim of this study was to measure trajectories of craving for methamphetamine
during the course of pharmacotherapy trials for methamphetamine use disorder. Design …
during the course of pharmacotherapy trials for methamphetamine use disorder. Design …
Neurobiology of the incubation of drug craving: an update
Relapse to drug use is often preceded by drug craving. Clinical observations in the 1980s
led clinical investigators to postulate that cue-induced cocaine craving may increase during …
led clinical investigators to postulate that cue-induced cocaine craving may increase during …