Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino
acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved …

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are
highly dependent on nutrients in order to duplicate their cell mass during each cell division …

Amino acids are indispensable for the growth of cancer cells. This includes essential amino
acids, the carbon skeleton of which cannot be synthesized, and conditionally essential …

The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …

Serine is a vital amino acid in tumorigenesis. While cells can perform de novo serine
synthesis, most transformed cells rely on serine uptake to meet their increased biosynthetic …

Drosophila Lgl and its mammalian homologues, LLGL1 and LLGL2, are scaffolding proteins
that regulate the establishment of apical–basal polarity in epithelial cells,. Whereas Lgl …

The large neutral amino acid transporter 1 (LAT1, or SLC7A5) is a sodium-and pH-
independent transporter, which supplies essential amino acids (eg, leucine, phenylalanine) …

Membrane proteins play essential roles in various cellular processes, such as nutrient
transport, bioenergetic processes, cell adhesion, and signal transduction. Proteomics is one …

Background Tumor angiogenesis is regarded as a rational anti-cancer target. The efficacy
and indications of anti-angiogenic therapies in clinical practice, however, are relatively …