Multidrug-resistant bacteria in the community: trends and lessons learned

D Van Duin, DL Paterson - Infectious disease clinics, 2016 - id.theclinics.com
Multidrug resistant (MDR) bacteria are well-recognized to be one of the most important
current public health problems. The Infectious Diseases Society of America recognizes …

Multidrug‐resistant bacteria: their mechanism of action and prophylaxis

A Bharadwaj, A Rastogi, S Pandey… - BioMed research …, 2022 - Wiley Online Library
In the present scenario, resistance to antibiotics is one of the crucial issues related to public
health. Earlier, such resistance to antibiotics was limited to nosocomial infections, but it has …

[HTML][HTML] Bacterial communities in semen from men of infertile couples: metagenomic sequencing reveals relationships of seminal microbiota to semen quality

SL Weng, CM Chiu, FM Lin, WC Huang, C Liang… - PloS one, 2014 - journals.plos.org
Some previous studies have identified bacteria in semen as being a potential factor in male
infertility. However, only few types of bacteria were taken into consideration while using PCR …

Influence of Virulence Genotype and Resistance Profile in the Mortality of Pseudomonas aeruginosa Bloodstream Infections

C Peña, G Cabot, S Gómez-Zorrilla… - Clinical Infectious …, 2015 - academic.oup.com
Using a large multicenter prospective cohort of Pseudomonas aeruginosa bacteremia, we
demonstrate that the exoU type III secretion system genotype is independently associated …

Host and Pathogen Biomarkers for Severe Pseudomonas aeruginosa Infections

C Juan, C Peña, A Oliver - The Journal of infectious diseases, 2017 - academic.oup.com
Pseudomonas aeruginosa is among the leading causes of severe nosocomial infections,
particularly affecting critically ill and immunocompromised patients. Here we review the …

[HTML][HTML] Phase 1 study of MEDI3902, an investigational anti–Pseudomonas aeruginosa PcrV and Psl bispecific human monoclonal antibody, in healthy adults

SO Ali, XQ Yu, GJ Robbie, Y Wu, K Shoemaker… - Clinical microbiology …, 2019 - Elsevier
Objectives MEDI3902 is a bivalent, bispecific human immunoglobulin G1κ monoclonal
antibody that binds to both the Pseudomonas aeruginosa PcrV protein involved in host cell …

Multidrug-resistant bacteria in the community: an update

D van Duin, DL Paterson - Infectious Disease Clinics, 2020 - id.theclinics.com
Multidrug-resistant (MDR) bacteria are well-recognized to be one of the most important
current public health problems. More than 2.8 million antibiotic-resistant infections occur in …

Lysocins: bioengineered antimicrobials that deliver lysins across the outer membrane of Gram-negative bacteria

RD Heselpoth, CW Euler, R Schuch… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
The prevalence of multidrug-resistant Pseudomonas aeruginosa has stimulated
development of alternative therapeutics. Bacteriophage peptidoglycan hydrolases, termed …

[HTML][HTML] The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response

T Sawa - Journal of intensive care, 2014 - Springer
Pseudomonas aeruginosa is the most common gram-negative pathogen causing
pneumonia in immunocompromised patients. Acute lung injury induced by bacterial …

Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media

CR Belanger, AHY Lee, D Pletzer… - Proceedings of the …, 2020 - National Acad Sciences
Pseudomonas aeruginosa causes severe multidrug-resistant infections that often lead to
bacteremia and sepsis. Physiologically relevant conditions can increase the susceptibility of …