Quadruplex nucleic acids as novel therapeutic targets
S Neidle - Journal of medicinal chemistry, 2016 - ACS Publications
Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
RNA G-quadruplexes in biology: principles and molecular mechanisms
Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …
formed by sequences rich in guanine. These structures are implicated in many essential …
High-throughput sequencing of DNA G-quadruplex structures in the human genome
VS Chambers, G Marsico, JM Boutell… - Nature …, 2015 - nature.com
Abstract G-quadruplexes (G4s) are nucleic acid secondary structures that form within
guanine-rich DNA or RNA sequences. G4 formation can affect chromatin architecture and …
guanine-rich DNA or RNA sequences. G4 formation can affect chromatin architecture and …
Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …
rich sequences, and has profound implications for various pharmacological and biological …
A guide to computational methods for G-quadruplex prediction
E Puig Lombardi, A Londoño-Vallejo - Nucleic acids research, 2020 - academic.oup.com
Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-
quadruplexes (G4). Recent methodological developments have allowed the characterization …
quadruplexes (G4). Recent methodological developments have allowed the characterization …
Genome-wide mapping of G-quadruplex structures with CUT&Tag
J Lyu, R Shao, PY Kwong Yung… - Nucleic acids …, 2022 - academic.oup.com
Single-stranded genomic DNA can fold into G-quadruplex (G4) structures or form DNA: RNA
hybrids (R loops). Recent evidence suggests that such non-canonical DNA structures affect …
hybrids (R loops). Recent evidence suggests that such non-canonical DNA structures affect …
Thioflavin T as an efficient inducer and selective fluorescent sensor for the human telomeric G-quadruplex DNA
The quest for a G-quadruplex specific fluorescent sensor among other DNA forms under
physiological salt conditions has been addressed in this article. We demonstrate for the first …
physiological salt conditions has been addressed in this article. We demonstrate for the first …
G-quadruplexes: a promising target for cancer therapy
DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …
particular nucleic acid structure was discussed to play a role in malignant transformation and …
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
G-quadruplexes are four-stranded DNA structures that are over-represented in gene
promoter regions and are viewed as emerging therapeutic targets in oncology, as …
promoter regions and are viewed as emerging therapeutic targets in oncology, as …
Quadruplex DNA: sequence, topology and structure
ABSTRACT G-quadruplexes are higher-order DNA and RNA structures formed from G-rich
sequences that are built around tetrads of hydrogen-bonded guanine bases. Potential …
sequences that are built around tetrads of hydrogen-bonded guanine bases. Potential …