The 5-nitroimidazole drug metronidazole has remained the drug of choice in the treatment of
anaerobic infections, parasitic as well as bacterial, ever since its development in 1959. In …

Infectious diseases claim millions of lives every year, but with the advent of drug resistance,
therapeutic options to treat infections are inadequate. There is now an urgent need to …

Design of endogenous stimuli-responsive amino acids allows for precisely modulating
proteins or peptides under a biological microenvironment and thereby regulating their …

Metronidazole (Mtz) is a critical component of combination therapies that are used against
Helicobacter pylori, the major cause of peptic ulcer disease. Many H. pylori strains are Mtz …

Mycobacterium tuberculosis (Mtb) is a metabolically flexible pathogen that has the
extraordinary ability to sense and adapt to the continuously changing host environment …

Helicobacter pylori, a human pathogen with a high global prevalence, is the causative
pathogen for multiple gastrointestinal diseases, especially chronic gastritis, peptic ulcers …

Background: We systematically reviewed all available data in the literature to determine the
overall eradication rates of currently advised Helicobacter pylori eradication regimens and to …

Helicobacter pylori (H. pylori) antibiotic resistance is the main factor affecting the efficacy of
the current eradicating therapies. The aim of this editorial is to report on the recent …

Resistance of Helicobacter pylori to antibiotics included in current regimens used to
eradicate H. pylori is a major reason for failure. The definition of resistance is not simple, and …

Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills
Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species …