Lipids play important roles in energy metabolism along with diverse aspects of biological
membrane structure, signaling and other functions. Perturbations of lipid metabolism are …

Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Many
lines of evidence suggest that the disturbances in circadian rhythm are responsible for the …

Melatonin is an important endogenous hormone that modulates homeostasis in the
microenvironment. Recent studies have indicated that serum melatonin levels are closely …

Background Patients with major depression exhibit circadian disturbance of sleep and
mood, and when they are discharged from inpatient wards, this disturbance poses a risk of …

This narrative review briefly describes the mammalian circadian timing system, the specific
features of the liver clock, also by comparison with other peripheral clocks, the role of the …

Most living organisms in both the plant and animal kingdoms have evolved processes to
stay in tune with the alternation of day and night, and to optimize their physiology as a …

Simple Summary Cytochrome P450 Family 1 Subfamily B Member 1 (CYP1B1) is a critical
metabolic enzyme of melatonin. Although melatonin has been identified to exhibit tumor …

Identified more than two centuries ago, cholesterol plays a pivotal role in human physiology.
Since cholesterol metabolism is a physiologically significant process, it is not surprising that …

Featured Application Compromised light perception, as with retinal ganglion cell loss, is
associated with serum lipids being unevenly altered in the morning vs. the evening …

Rhythmic hormonal secretion is key for sustaining health. While a central pacemaker in the
hypothalamus is the main driver of circadian periodicity, many hormones oscillate with …