Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Carotenoids represent a large class of terpenoids characterized by an extensively
conjugated polyene chain. The conjugation system imparts carotenoids with excellent light …

R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

The recently discovered non-mevalonate biosynthetic route to isoprenoid precursors is an
essential metabolic pathway in plants, apicomplexan parasites, and many species of …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

The key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, 1-deoxy-d-
xylulose 5-phosphate reductoisomerase (DXR) has been shown to be the target enzyme of …

To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

Mycobacteria have a unique cell wall, which is rich in drug targets. The cell wall core
consists of a peptidoglycan layer, a mycolic acid layer, and an arabinogalactan …

The 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for isoprenoid biosynthesis has
come under increased scrutiny as a target for novel antimalarial, antibacterial and herbicidal …

Isopentenyl diphosphate is the precursor of various isoprenoids that are essential to all
living organisms. It is produced by the mevalonate pathway in humans but by an alternate …