In 1919, glucose intolerance became the earliest recognized metabolic abnormality in
cancer patients. Prior to the development of severe malnutrition, colon, gastric, sarcoma …

I. Introduction..................................................................... 477 II. Anorexia, Cause or
Effect?.......................................................... 478 III. Energetic Inefficiency …

This fifth article continues the series on unconventional therapies for cancer. The purpose
and methodology of the review appear in part 1 (CMAJ 1998; 158 [7]: 897-902). Annotated …

It is widely acknowledged that cancer cell energy metabolism relies mainly on anaerobic
glycolysis; this phenomenon is described as the Warburg effect. However, whether the …

Cancer cachexia is a complex syndrome characterized primarily by diminished nutrient
intake and progressive tissue depletion that is manifest clinically as anorexia and host …

Background & aims It is widely acknowledged that the energy metabolism of cancer cells
mainly relies on anaerobic glycolysis and this has prompted many researchers to try to …

In the past 20 years, cachexia in cancer patients has attracted increasing interest from both
clinicians and basic researchers. It is now clear that the cachexia is secondary to major …

Weight loss and malnutrition have long been associated with a poor clinical outcome after
surgery (1). Anorexia, muscle wasting and progressive depletion of adipose tissue have …

Cachexia occurs in the majority of cancer patients before death. It is the result of major
metabolic changes produced by tumor-released substances as well as by cytokines and …

Background: The role of gluconeogenesis from protein in the pathogenesis of weight loss in
lung cancer is unclear. Objective: Our aim was to study gluconeogenesis from alanine in …