The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …

Chromatin inheritance entails de novo nucleosome assembly after DNA replication by
chromatin assembly factor-1 (CAF-1). Yet direct knowledge about CAF-1's histone binding …

The functional organization of eukaryotic DNA into chromatin uses histones as components
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …

The mechanism of activation of the alternative lengthening of telomeres (ALT) pathway of
mammalian chromosome-end maintenance has been unclear. We have now discovered …

Senescence is characterized by an irreversible cell proliferation arrest. Specialized domains
of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF) …

The genome is subject to a diverse array of epigenetic modifications from DNA methylation
to histone posttranslational changes. Many of these marks are somatically stable through …

Plants can sense temperature changes and adjust their development and morphology
accordingly in a process called thermomorphogenesis. This phenotypic plasticity implies …

To restore chromatin on new DNA during replication, recycling of histones evicted ahead of
the fork is combined with new histone deposition. The Asf1 histone chaperone, which buffers …