Adaptive immune cell function is regulated by a highly diverse receptor recombined from
variable germline-encoded segments that can recognize an almost unlimited array of …

Therapeutic antibodies are at the forefront of biotherapeutics, valued for their high target
specificity and binding affinity. Despite their potential, optimizing antibodies for superior …

Protein language models (PLMs) based on machine learning have demon-strated
impressive success in predicting protein structure and function. However, general-purpose …

The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the main target of
neutralizing antibodies. Although they are infrequently elicited during infection or …

H5 influenza is considered a potential pandemic threat. Recently, H5 viruses belonging to
clade 2.3. 4.4 b have caused large outbreaks in avian and multiple non-human mammalian …

The family of human G protein–coupled receptors (GPCRs) comprises about 800 different
members, with about 35% of current pharmaceutical drugs targeting GPCRs. However …

Over the past two decades, therapeutic antibodies have emerged as a rapidly expanding
domain within the field of biologics. In silico tools that can streamline the process of antibody …

Sometime during the Covid-19 pan-demic I noticed certain changes in my behaviour. For
example, when someone was approaching me on the sidewalk, I switched to the other side …

Nanobodies, the smallest functional antibody fragment derived from camelid heavy‐chain‐
only antibodies, have emerged as powerful tools for diverse biomedical applications. In this …

Antibody discovery is crucial for developing therapeutics and vaccines as well as
understanding adaptive immunity. However, the lack of approaches to synthesize antibodies …