Werner syndrome (WS) is an autosomal recessive disease manifested by the premature
onset of age-related phenotypes, including diseases such as atherosclerosis and cancer …

Radiation generates reactive oxygen species (ROS) that interact with cellular molecules,
including DNA, lipids, and proteins. To know how ROS contribute to the induction of genetic …

Human aging is a complex process that leads to the gradual deterioration of body functions
with time. Various models to approach the study of aging have been launched over the …

Reduced replicative capacity is a consistent characteristic of cells derived from patients with
Werner syndrome. This premature senescence is phenotypically similar to replicative …

Exposure of cells to ultraviolet (UV)-A radiation induces oxidative damage in DNA, such as 8-
oxo-7, 8-dihydroguanine (8-oxoG), single-strand breaks, a-basic sites, and DNA–protein …

Werner syndrome (WS) is a premature aging syndrome caused by mutations of the WRN
gene. Here, we demonstrate that a strain of WS fibroblast cells shows abnormal karyotypes …

Werner syndrome is a genetic disease characterized by early ageing, excess cancer risk,
high incidence of type II diabetes mellitus, early atherosclerosis, ocular cataracts, and …

The gene responsible for ataxia telangiectasia (AT) encodes ATM protein, which plays a
major role in the network of a signal transduction initiated by double strand DNA breaks. To …

Werner syndrome (WS) is a rare autosomal progeroid disorder caused by a mutation in the
gene encoding the WRN (Werner syndrome protein), a member of the RecQ family of …

Studying monogenic hereditary disorders that manifest age-related phenotypes in cells,
tissues, and the total organism would be helpful for clarifying the mechanisms of aging. In …