Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?
CB Mishra, M Tiwari, CT Supuran - Medicinal Research …, 2020 - Wiley Online Library
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are widely distributed metalloenzymes in
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …
Bacterial, fungal and protozoan carbonic anhydrases as drug targets
C Capasso, CT Supuran - Expert opinion on therapeutic targets, 2015 - Taylor & Francis
Introduction: The carbonic anhydrases (CAs, EC 4.2. 1.1), a group of ubiquitously expressed
metalloenzymes, are involved in numerous physiological and pathological processes, as …
metalloenzymes, are involved in numerous physiological and pathological processes, as …
Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
A series of substituted pyrazole compounds (1–8 and 9a, b) were synthesized and their
structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole …
structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole …
Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors
S Burmaoglu, AO Yilmaz, MF Polat, R Kaya, İ Gulcin… - Bioorganic …, 2019 - Elsevier
A novel class of fluoro-substituted tris-chalcones derivatives (5a-5i) was synthesized from
phloroglucinol and corresponding benzaldehydes. A three step synthesis method was …
phloroglucinol and corresponding benzaldehydes. A three step synthesis method was …
Isofraxidin: Antioxidant, Anti‐carbonic Anhydrase, Anti‐cholinesterase, Anti‐diabetic, and in Silico Properties
The development of innovative pharmacological formulations for the treatment and
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …
The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products
Starting from vanillin, known four benzyl bromides with Br were synthesized. The first
synthesis of natural product 3, 4-dibromo-5-((methylsulfonyl) methyl) benzene-1, 2-diol (2) …
synthesis of natural product 3, 4-dibromo-5-((methylsulfonyl) methyl) benzene-1, 2-diol (2) …
Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds–determination of their carbonic anhydrase, acetylcholinesterase …
Abstract Sulfur-containing pyrroles (1–3), tris (2-pyridyl) phosphine (selenide) sulfide (4–5)
and 4-benzyl-6-(thiophen-2-yl) pyrimidin-2-amine (6) were synthesized and characterized …
and 4-benzyl-6-(thiophen-2-yl) pyrimidin-2-amine (6) were synthesized and characterized …
Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives
In this study, series of novel bromophenol derivatives were synthesized and investigated for
their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were …
their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were …
Synthesis, characterization, crystal structure of novel bis-thiomethylcyclohexanone derivatives and their inhibitory properties against some metabolic enzymes
In this study, a series of novel bis-thiomethylcyclohexanone compounds (3a–3j) were
synthesized by the addition of thio-Michael to the bis-chalcones under mild reaction …
synthesized by the addition of thio-Michael to the bis-chalcones under mild reaction …
Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
In this study, a series of novel bromophenols were synthesized from benzoic acids and
methoxylated bromophenols. The synthesized compounds were evaluated by using different …
methoxylated bromophenols. The synthesized compounds were evaluated by using different …