Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

The application of antibodies in enzyme-linked immunosorbent assay (ELISA) is the basis of
this diagnostic technique which is designed to detect a potpourri of complex target …

G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich
oligonucleotides of DNA-or RNA-type. Depending on their chemical nature, loops length …

Aptamers are molecular recognition elements made of nucleic acids. Diverse synthetic
aptamers have been discovered in a large number of SELEX experiments since 1990. This …

Certain guanine-rich (G-rich) DNA and RNA molecules can associate intermolecularly or
intramolecularly to form four stranded or “quadruplex” structures, which have unusual …

Aptamers are single stranded oligonucleotides that bind a wide range of biological targets.
Although aptamers can be isolated from pools of random sequence oligonucleotides using …

The detection of nucleic acids and proteins is fundamental for studying their functions and
for the development of molecular diagnostics. These molecules carry out most biological …

Abstract G-quadruplex (G4) is a non-canonical structure that is formed in G-rich sequences
of nucleic acids. G4s play important roles in vivo, such as telomere maintenance …

Herein a hybrid catalyst consisting of “naked” Au-NPs in situ grown on graphene sheets is
engineered, which exhibits a synergetic effect in mimicking peroxidase at its interface …

Conspectus Although antibodies are a powerful tool for molecular biology and clinical
diagnostics, there are many emerging applications for which nucleic acid-based aptamers …