Artificial intelligence-powered microfluidics for nanomedicine and materials synthesis

L Liu, M Bi, Y Wang, J Liu, X Jiang, Z Xu, X Zhang - Nanoscale, 2021 - pubs.rsc.org
Artificial intelligence (AI) is an emerging technology with great potential, and its robust
calculation and analysis capabilities are unmatched by traditional calculation tools. With the …

AI-powered microfluidics: shaping the future of phenotypic drug discovery

J Liu, H Du, L Huang, W Xie, K Liu… - … Applied Materials & …, 2024 - ACS Publications
Phenotypic drug discovery (PDD), which involves harnessing biological systems directly to
uncover effective drugs, has undergone a resurgence in recent years. The rapid …

A comparison of microfluidic methods for high-throughput cell deformability measurements

M Urbanska, HE Muñoz, J Shaw Bagnall, O Otto… - Nature …, 2020 - nature.com
The mechanical phenotype of a cell is an inherent biophysical marker of its state and
function, with many applications in basic and applied biological research. Microfluidics …

[HTML][HTML] Cancer cells resist mechanical destruction in circulation via RhoA/actomyosin-dependent mechano-adaptation

DL Moose, BL Krog, TH Kim, L Zhao, S Williams-Perez… - Cell reports, 2020 - cell.com
During metastasis, cancer cells are exposed to potentially destructive hemodynamic forces
including fluid shear stress (FSS) while en route to distant sites. However, prior work …

A review on recent advances of AI-integrated microfluidics for analytical and bioanalytical applications

E Asadian, F Bahramian, S Siavashy… - TrAC Trends in …, 2024 - Elsevier
In today's biomedical research, the pursuit of diagnostic tools boasting maximum precision
and accuracy while minimizing sample volume and pre-treatment requirements, has …

Cells nanomechanics by atomic force microscopy: focus on interactions at nanoscale

G Zhou, B Zhang, G Tang, XF Yu… - Advances in Physics …, 2021 - Taylor & Francis
Nanomechanics of cytoskeleton is deeply involved in physiology and regulation of cell
behavior. Atomic Force Microscopy has been extensively used for quantitative …

A unified rheological model for cells and cellularised materials

A Bonfanti, J Fouchard… - Royal Society …, 2020 - royalsocietypublishing.org
The mechanical response of single cells and tissues exhibits a broad distribution of time-
scales that often gives rise to a distinctive power-law rheology. Such complex behaviour …

[HTML][HTML] Cancer cell mechanobiology: a new frontier for cancer research

W Yu, S Sharma, E Rao, AC Rowat… - Journal of the National …, 2022 - Elsevier
The study of physical and mechanical features of cancer cells, or cancer cell
mechanobiology, is a new frontier in cancer research. Such studies may enhance our …

Fluid shear stress coupled with narrow constrictions induce cell type-dependent morphological and molecular changes in SK-BR-3 and MDA-MB-231 cells

HA Cognart, JL Viovy, C Villard - Scientific reports, 2020 - nature.com
Cancer mortality mainly arises from metastases, due to cells that escape from a primary
tumor, circulate in the blood as circulating tumor cells (CTCs), permeate across blood …

Glioma Single-Cell Biomechanical Analysis by Cyclic Conical Constricted Microfluidics

X Geng, ZA Zhou, Y Mi, C Wang, M Wang… - Analytical …, 2023 - ACS Publications
Determining the grade of glioma is a critical step in choosing patients' treatment plans in
clinical practices. The pathological diagnosis of patient's glioma samples requires extensive …