Ca2+ is well established as an intracellular second messenger. However, the molecular
identification of a detector for extracellular Ca2+—the extracellular calcium-sensing receptor …

Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

Abstract Increased extracellular Ca2+ concentrations ([Ca2+] ex) trigger activation of the
NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR). To prevent …

Activation of the NLRP3 inflammasome enables monocytes and macrophages to release
high levels of interleukin-1β during inflammatory responses. Concentrations of extracellular …

Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range
of cellular processes, such as gene transcription (see Mellström and Naranjo, this issue) …

Store-operated Ca2+ entry (SOCE) has been associated with two types of channels: CRAC
channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and …

The discovery of a G protein–coupled, calcium-sensing receptor (CaR) a decade ago and of
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …

Evolution has exploited the chemical properties of Ca 2+, which facilitate its reversible
binding to the sites of irregular geometry offered by biological macromolecules, to select it as …

Homomeric acid-sensing ion channel 1 (ASIC1) can be activated by extracellular H+ in the
physiological pH range and may, therefore, contribute to neurotransmission and peripheral …

We have investigated mechanisms of mitochondrial stress-induced phenotypic changes and
cell invasion in tumorigenic but poorly invasive human pulmonary carcinoma A549 cells that …