Extracellular calcium sensing and signalling
AM Hofer, EM Brown - Nature reviews Molecular cell biology, 2003 - nature.com
Ca2+ is well established as an intracellular second messenger. However, the molecular
identification of a detector for extracellular Ca2+—the extracellular calcium-sensing receptor …
identification of a detector for extracellular Ca2+—the extracellular calcium-sensing receptor …
Intercellular Ca2+ Waves: Mechanisms and Function
L Leybaert, MJ Sanderson - Physiological reviews, 2012 - journals.physiology.org
Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …
[HTML][HTML] Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
Abstract Increased extracellular Ca2+ concentrations ([Ca2+] ex) trigger activation of the
NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR). To prevent …
NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR). To prevent …
[HTML][HTML] Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
M Rossol, M Pierer, N Raulien, D Quandt… - Nature …, 2012 - nature.com
Activation of the NLRP3 inflammasome enables monocytes and macrophages to release
high levels of interleukin-1β during inflammatory responses. Concentrations of extracellular …
high levels of interleukin-1β during inflammatory responses. Concentrations of extracellular …
Calcium signalling—an overview
Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range
of cellular processes, such as gene transcription (see Mellström and Naranjo, this issue) …
of cellular processes, such as gene transcription (see Mellström and Naranjo, this issue) …
[HTML][HTML] Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions
KT Cheng, X Liu, HL Ong, W Swaim, IS Ambudkar - PLoS biology, 2011 - journals.plos.org
Store-operated Ca2+ entry (SOCE) has been associated with two types of channels: CRAC
channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and …
channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and …
The calcium-sensing receptor in normal physiology and pathophysiology: a review
J Tfelt-Hansen, EM Brown - Critical reviews in clinical laboratory …, 2005 - Taylor & Francis
The discovery of a G protein–coupled, calcium-sensing receptor (CaR) a decade ago and of
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …
Calcium in health and disease
Evolution has exploited the chemical properties of Ca 2+, which facilitate its reversible
binding to the sites of irregular geometry offered by biological macromolecules, to select it as …
binding to the sites of irregular geometry offered by biological macromolecules, to select it as …
[HTML][HTML] Alternative splicing and interaction with di-and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1)
E Babini, M Paukert, HS Geisler, S Gründer - Journal of Biological …, 2002 - ASBMB
Homomeric acid-sensing ion channel 1 (ASIC1) can be activated by extracellular H+ in the
physiological pH range and may, therefore, contribute to neurotransmission and peripheral …
physiological pH range and may, therefore, contribute to neurotransmission and peripheral …
Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells
G Amuthan, G Biswas, HK Ananadatheerthavarada… - Oncogene, 2002 - nature.com
We have investigated mechanisms of mitochondrial stress-induced phenotypic changes and
cell invasion in tumorigenic but poorly invasive human pulmonary carcinoma A549 cells that …
cell invasion in tumorigenic but poorly invasive human pulmonary carcinoma A549 cells that …