An overview of autism spectrum disorder, heterogeneity and treatment options
Since the documented observations of Kanner in 1943, there has been great debate about
the diagnoses, the sub-types, and the diagnostic threshold that relates to what is now known …
the diagnoses, the sub-types, and the diagnostic threshold that relates to what is now known …
Autism genetics: opportunities and challenges for clinical translation
Genetic studies have revealed the involvement of hundreds of gene variants in autism. Their
risk effects are highly variable, and they are frequently related to other conditions besides …
risk effects are highly variable, and they are frequently related to other conditions besides …
T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control
Antigen-specific CD8+ T cell accumulation in tumors is a prerequisite for effective
immunotherapy, and yet the mechanisms of lymphocyte transit are not well defined. Here we …
immunotherapy, and yet the mechanisms of lymphocyte transit are not well defined. Here we …
Inherited and de novo genetic risk for autism impacts shared networks
We performed a comprehensive assessment of rare inherited variation in autism spectrum
disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families …
disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families …
Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk
We address the challenge of detecting the contribution of noncoding mutations to disease
with a deep-learning-based framework that predicts the specific regulatory effects and the …
with a deep-learning-based framework that predicts the specific regulatory effects and the …
Emerging connections between cerebellar development, behaviour and complex brain disorders
A Sathyanesan, J Zhou, J Scafidi, DH Heck… - Nature Reviews …, 2019 - nature.com
The human cerebellum has a protracted developmental timeline compared with the
neocortex, expanding the window of vulnerability to neurological disorders. As the …
neocortex, expanding the window of vulnerability to neurological disorders. As the …
The ASD Living Biology: from cell proliferation to clinical phenotype
E Courchesne, T Pramparo, VH Gazestani… - Molecular …, 2019 - nature.com
Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the
lay public because of its uncertain origins and striking and unexplained clinical …
lay public because of its uncertain origins and striking and unexplained clinical …
Applications of supervised machine learning in autism spectrum disorder research: a review
Autism spectrum disorder (ASD) research has yet to leverage “big data” on the same scale
as other fields; however, advancements in easy, affordable data collection and analysis may …
as other fields; however, advancements in easy, affordable data collection and analysis may …
Single-cell transcriptomic analysis of mouse neocortical development
The development of the mammalian cerebral cortex depends on careful orchestration of
proliferation, maturation, and migration events, ultimately giving rise to a wide variety of …
proliferation, maturation, and migration events, ultimately giving rise to a wide variety of …
Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes
Autism spectrum disorder (ASD) is a genetically heterogeneous condition, caused by a
combination of rare de novo and inherited variants as well as common variants in at least …
combination of rare de novo and inherited variants as well as common variants in at least …