Arterial and venous thromboembolism are leading causes of morbidity and mortality around
the world. For almost 70 years, heparins (unfractionated heparin and low molecular weight …

Heparin is a life-saving drug, which belongs to few clinically used drugs without defined
molecular structures in modern medicine. Heparin is the mostly negatively charged …

Existing anticoagulants effectively inhibit the activity of coagulation factors of the extrinsic
and common pathway but have substantial limitations and can cause severe bleeding …

The Vitamin K antagonist warfarin was the only oral anticoagulant available for decades for
the treatment of thrombosis and prevention of thromboembolism until Direct Oral …

This review provides an update on laboratory testing and monitoring for existing and
emerging anticoagulants, starting with an overview of haemostasis and the routine …

Background Adults who require long-term anticoagulation with low-molecular-weight
heparin (LMWH) such as cancer patients or the elderly may be at increased risk of fractures …

Background The rapid reversal of the effects of vitamin K antagonists is often required in
cases of emergency surgery and life-threatening bleeding, or during bleeding associated …

Hemostasis is traditionally defined as the physiologic process whereby bleeding is
antagonized and possibly stopped to minimize blood loss. The first medical description of …

Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism,
is a leading health-care problem whose pathogenesis is usually related to the so-called …

A native fucosylated glycosaminoglycan from sea cucumber Holothuria fuscopunctata
(nHG), mainly branched with Fuc 3S4S, exhibited potent anticoagulant activity by intrinsic …