Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Despite several decades of intense research focused on understanding function (s) and
disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly …

Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses,
including aberrant oncogene activation, telomere shortening, and DNA damage. Through a …

Recent findings suggest that the ribosome itself modulates gene expression. However,
whether ribosomes change composition across cell types or control cell fate remains …

The continued integrity of biological systems depends on a balance between
interdependent elements at the molecular, cellular, and organismal levels. This is …

The p53 transcription factor drives anti-proliferative gene expression programs in response
to diverse stressors, including DNA damage and oncogenic signaling. Here, we seek to …

Understanding the mechanisms underlying cancer gene expression is critical for precision
oncology. Posttranscriptional regulation is a key determinant of protein abundance and …

Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate, but it
is not known whether the metabolic regulation of protein synthesis controls HSPC …

Transposable elements (TEs) are indispensable for human development, with critical
functions in pluripotency and embryogenesis. TE sequences also contribute to human …

Although features of ribosome assembly are shared between species, our understanding of
the diversity, complexity, dynamics, and regulation of ribosome production in multicellular …