Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

The essential amino acid tryptophan (Trp) is metabolized by gut commensals, yielding in
compounds that affect innate immune cell functions directly, but also acting on the aryl …

Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are
women and it has a population prevalence of about 1%, but evidence-based treatment is …

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a common but
poorly understood form of heart failure, characterized by impaired diastolic function. It is …

Dysbiosis, generally defined as the disruption to gut microbiota composition or function, is
observed in most diseases, including allergies, cancer, metabolic diseases, neurological …

BACKGROUND: Tryptophan metabolism is important in blood pressure regulation. The
tryptophan-indole pathway is exclusively mediated by the gut microbiota. ACE2 (angiotensin …

Tryptophan (TRP) contributes to individual immune homeostasis and good condition via
three complex metabolism pathways (5-hydroxytryptamine (5-HT), kynurenine (KP), and gut …

The intricate interplay between gut microbiota and the host is pivotal in maintaining
homeostasis and health. Dietary tryptophan (TRP) metabolism initiates a cascade of …

The gut microbiota constitutes a complex ecosystem, comprising trillions of microbes that
have co-evolved with their host over hundreds of millions of years. Over the past decade, a …

Cardiovascular diseases (CVDs) are the leading cause of premature morbidity and mortality
globally. The identification of novel risk factors contributing to CVD onset and progression …