The year 2021 marks the centennial of Banting and Best's landmark description of the
discovery of insulin. This discovery and insulin's rapid clinical deployment effectively …

Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic β-cells (or β-
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …

Recent clinical data have suggested a correlation between coronavirus disease 2019
(COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in …

The increasing availability of large-scale single-cell atlases has enabled the detailed
description of cell states. In parallel, advances in deep learning allow rapid analysis of newly …

Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …

Pancreatic β-cell failure is a critical event in the onset of both main types of diabetes mellitus
but underlying mechanisms are not fully understood. β-cells have low anti-oxidant capacity …

During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress
and, therefore, require adaptive responses to survive. The adaptive mechanisms that can …

The notion that in diabetes pancreatic β-cells express endoplasmic reticulum (ER) stress
markers indicative of increased unfolded protein response (UPR) signaling is no longer in …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …