The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …

This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …

Akt/PKB is a serine/threonine kinase that promotes tumor cell growth by phosphorylating
transcription factors and cell cycle proteins. There is particular interest in finding tumor …

Abstract p53 is the most commonly mutated gene in human cancer. After activation by
cellular stresses such as DNA damage or oncogene activation, p53, a sequence-specific …

Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

Cancer cells undergo alterations in lipid metabolism to support their high energy needs,
tumorigenesis and evade an anti-tumor immune response. Alterations in fatty acid …

The 21st century will undoubtedly witness unprecedented advances in understanding the
mechanisms of the human body and in developing biotechnology. With the mapping of the …

Current knowledge about molecular mechanisms underlying disease progression and drug
resistance in multiple myeloma (MM) is still limited. Here, we analyzed the potential …

The tumor suppressor p53 is activated upon cellular stresses such as DNA damage,
oncogene activation, hypoxia, which transactivates sets of genes that induce DNA repair …