[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

The diversity and breadth of cancer cell fatty acid metabolism

SR Nagarajan, LM Butler, AJ Hoy - Cancer & Metabolism, 2021 - Springer
Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

Phosphatidylcholine-derived lipid mediators: The crosstalk between cancer cells and immune cells

RF Saito, LNS Andrade, SO Bustos… - Frontiers in …, 2022 - frontiersin.org
To become resistant, cancer cells need to activate and maintain molecular defense
mechanisms that depend on an energy trade-off between resistance and essential functions …

Why make it if you can take it: review on extracellular cholesterol uptake and its importance in breast and ovarian cancers

AR Lauridsen, A Skorda, NI Winther, ML Bay… - Journal of Experimental …, 2024 - Springer
Cholesterol homeostasis is essential for healthy mammalian cells and dysregulation of
cholesterol metabolism contributes to the pathogenesis of various diseases including …

Lipid metabolism and cancer

H Cheng, M Wang, J Su, Y Li, J Long, J Chu, X Wan… - Life, 2022 - mdpi.com
Lipid metabolism is involved in the regulation of numerous cellular processes, such as cell
growth, proliferation, differentiation, survival, apoptosis, inflammation, movement, membrane …

Reprogrammed lipid metabolism and the lipid-associated hallmarks of colorectal cancer

T Salita, YH Rustam, D Mouradov, OM Sieber, GE Reid - Cancers, 2022 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the third-most diagnosed cancer and the
second-leading cause of cancer-related deaths worldwide. Limitations in early and accurate …

Targeting lipid metabolism in metastatic prostate cancer

T Scheinberg, B Mak, L Butler… - … Advances in Medical …, 2023 - journals.sagepub.com
Despite key advances in the treatment of prostate cancer (PCa), a proportion of men have
de novo resistance, and all will develop resistance to current therapeutics over time …

[HTML][HTML] Plasma lipids signify the progression of precancerous gastric lesions to gastric cancer: a prospective targeted lipidomics study

ZC Liu, WH Wu, S Huang, ZW Li, X Li, GH Shui… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Gastric cancer (GC) is preceded by a stepwise progression of precancerous
gastric lesions. Distinguishing individuals with precancerous gastric lesions that have …

Therapeutic potential of NR4A1 in cancer: Focus on metabolism

S Deng, B Chen, J Huo, X Liu - Frontiers in oncology, 2022 - frontiersin.org
Metabolic reprogramming is a vital hallmark of cancer, and it provides the necessary energy
and biological materials to support the continuous proliferation and survival of tumor cells …

Diet modulates the gut microbiome, metabolism, and mammary gland inflammation to influence breast cancer risk

AA Arnone, AS Wilson, DR Soto-Pantoja… - Cancer Prevention …, 2024 - aacrjournals.org
Several studies indicate a strong link between obesity and the risk of breast cancer. Obesity
decreases gut microbial biodiversity and modulates Bacteroidetes-to-Firmicutes phyla …