G-protein-coupled receptors (GPCRs), which constitute the largest family of cell surface
receptors, were originally thought to function as monomers, but are now recognized as …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

The proposal of receptor-receptor interactions (RRIs) in the early 1980s broadened the view
on the role of G protein-coupled receptors (GPCR) in the dynamics of the intercellular …

The elusive nature of the structure and function of the G-protein coupled receptor (GPCR)
dimer or oligomer has led to a variety of computational studies, most of which have been …

The accurate identification of the specific points of interaction between G protein-coupled
receptor (GPCR) oligomers is essential for the design of receptor ligands targeting …

GPCR oligomerization has emerged as a hot topic in the GPCR field in the last years.
Receptors that are part of these oligomers can influence each other's function, although it is …

Abstract G Protein-Coupled Receptors (GPCRs) can form homo-and heterodimers or
constitute higher oligomeric clusters with other heptahelical GPCRs. In this article, multiscale …

Recent research has unveiled the complexity of mechanisms involved in G protein-coupled
receptor (GPCR) functioning in which receptor dimerization/oligomerization may play an …

In spite of the ever-increasing evidence that G protein-coupled receptors (GPCRs) form
dimers/oligomers, the biological role (s) and structural architecture of homologous and …

The design of new drugs that target vasopressin 2 receptor (V2R) is of vital importance to
develop new therapeutic alternatives to treat diseases such as heart failure, polycystic …