Interleukin-1 (IL-1) family of cytokines: role in type 2 diabetes

M Banerjee, M Saxena - Clinica chimica acta, 2012 - Elsevier
Cytokines are small cell signaling protein molecules which encompass a large and diverse
family. They consist of immunomodulating agents such as interleukins and inteferons …

Mechanisms underlying the comorbidity of schizophrenia and type 2 diabetes mellitus

Y Mizuki, S Sakamoto, Y Okahisa… - International Journal …, 2021 - academic.oup.com
The mortality rate of patients with schizophrenia is high, and life expectancy is shorter by 10
to 20 years. Metabolic abnormalities including type 2 diabetes mellitus (T2DM) are among …

[HTML][HTML] TNF-α modulation of intestinal tight junction permeability is mediated by NIK/IKK-α axis activation of the canonical NF-κB pathway

R Al-Sadi, S Guo, D Ye, M Rawat, TY Ma - The American journal of …, 2016 - Elsevier
Tumor necrosis factor (TNF)-α, a key mediator of intestinal inflammation, causes an increase
in intestinal epithelial tight junction (TJ) permeability by activating myosin light chain kinase …

[HTML][HTML] Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus

M Banerjee, M Saxena - World journal of diabetes, 2014 - ncbi.nlm.nih.gov
Diabetes mellitus is a combined metabolic disorder which includes hyperglycemia,
dyslipidemia, stroke and several other complications. Various groups all over the world are …

[PDF][PDF] The genetics of type 2 diabetes mellitus: a review

S Singh - J Sci Res, 2011 - researchgate.net
Variants of a number of genes have been associated to Type 2 Diabetes Mellitus (T2D)
among Europeans. However, the contributions of these genetic variants in other ethnic …

IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia

P Linhartová, P Cernochova… - Oral diseases, 2013 - Wiley Online Library
Objective External apical root resorption (EARR) is permanent shortening of the end of the
tooth root. It is a common clinical complication of orthodontic treatment. Polymorphisms in …

Association between circulating interleukin-1 beta (IL-1β) levels and IL-1β C–511T polymorphism with cervical cancer risk in Egyptian women

MA Al-Tahhan, RL Etewa, MM El Behery - Molecular and cellular …, 2011 - Springer
Cancer cervix is one of the leading causes of cancer-related mortality among women
worldwide. It is believed that the host genetic factors such as inflammation-induced …

Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet

SWP Koppe, M Elias, RH Moseley… - American Journal of …, 2009 - journals.physiology.org
Diets high in trans fats are associated with an increased risk of cardiovascular disease and
components of the metabolic syndrome. The influence of these toxic fatty acids on the …

The role of TLR4, TNF‐α and IL‐1β in type 2 diabetes mellitus development within a North Indian population

NE Doody, MM Dowejko, EC Akam… - Annals of human …, 2017 - Wiley Online Library
This study investigated the role of IL‐1β‐511 (rs16944), TLR4‐896 (rs4986790) and TNF‐α‐
308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous …

Association between IL-1B (-511)/IL-1RN (VNTR) polymorphisms and type 2 diabetes: a systematic review and meta-analysis

J Jiao, Z Wang, Y Guo, J Liu, X Huang, X Ni, D Gao… - PeerJ, 2021 - peerj.com
Abstract Interleukin-1 (IL-1) plays an essential role in the immune pro-inflammatory process,
which is regarded as one of many factors in the development of type 2 diabetes mellitus …