RNA sequencing in situ allows for whole-transcriptome characterization at high resolution,
while retaining spatial information. These data present an analytical challenge for …

The immune system defines a complex network of tissues and cell types that orchestrate
responses across the body in a dynamic manner. The local and systemic interactions …

Rationale: Hepatocellular carcinoma (HCC) is a highly heterogeneous and malignant
disease with the complex immune microenvironment, which ultimately influence clinic …

Background DNA mismatch repair (MMR) deficiency has attracted considerable attention as
a predictor of the immunotherapy efficacy of solid tumors, including gastric cancer. We …

Background Spatial resolved transcriptomics (SRT) encompasses a rapidly developing set
of technologies that enable the measurement of gene expression in tissue while retaining …

Spatial transcriptomics (ST) assays represent a revolution in how the architecture of tissues
is studied by allowing for the exploration of cells in their spatial context. A common element …

Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage
melanoma patients. Here, we characterize the tumor microenvironment of LMD and patient …

Recent developments in spatially resolved transcriptomics (ST) have resulted in a large
number of studies characterizing the architecture of tissues, the spatial distribution of cell …

Cancer metastasis often leads to death and therapeutic resistance. This process involves
the participation of a variety of cell components, especially cellular and intercellular …

Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage
melanoma patients. The inaccessible nature of the disease site and lack of understanding of …