[图书][B] Model-based systems engineering with OPM and SysML
D Dori - 2016 - Springer
The quest for simplicity in a complex world has occupied thinkers for millennia. How to
conceptualize what humans observe around them and what they wish to design in order to …
conceptualize what humans observe around them and what they wish to design in order to …
Systems thinking of pre-and in-service science and engineering teachers
Systems thinking is an important skill in science and engineering education. Our study
objectives were (1) to create the basis for a systems thinking language common to both …
objectives were (1) to create the basis for a systems thinking language common to both …
The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins
B Blasco-Moreno, L de Campos-Mata… - Nature …, 2019 - nature.com
Abstract The highly conserved 5'–3'exonuclease Xrn1 regulates gene expression in
eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating …
eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating …
OPCloud: an OPM integrated conceptual‐executable modeling environment for industry 4.0
Summary This chapter presents Methodical Approach to Executable Integrated Modeling
(MAXIM) and its implementation environment, OPCloud. The MAXIM framework enables …
(MAXIM) and its implementation environment, OPCloud. The MAXIM framework enables …
Model-based interoperability engineering in systems-of-systems and civil aviation
Y Mordecai, O Orhof, D Dori - IEEE Transactions on Systems …, 2016 - ieeexplore.ieee.org
Interoperability is the capability of multiple parties and systems to collaborate and exchange
information and matter to obtain their objectives. Interoperability challenges call for a model …
information and matter to obtain their objectives. Interoperability challenges call for a model …
A model-based reverse system engineering methodology for analyzing complex biological systems with a case study in glycolysis
We propose a model-based reverse systems engineering (MBRSE) methodology for
biological systems that relies on requirements analysis in conjunction with model-based …
biological systems that relies on requirements analysis in conjunction with model-based …
Rpb4/7, a key element of RNA pol II to coordinate mRNA synthesis in the nucleus with cytoplasmic functions in Saccharomyces cerevisiae
AI Garrido-Godino, M Martín-Expósito… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Gene expression is a complex phenomenon that depends on multiple protein complexes,
including RNA polymerases (RNA pols). In eukaryotes, bacteria, and archaea, RNA pols are …
including RNA polymerases (RNA pols). In eukaryotes, bacteria, and archaea, RNA pols are …
Designing virtual chemistry visualizations featuring environmental dilemmas to promote equitable knowledge integration
Complex ideas in chemistry can be successfully captured in visualizations, simulations, and
virtual laboratories. 1–3 Chemistry research using online learning environments has …
virtual laboratories. 1–3 Chemistry research using online learning environments has …
Dissociation of Rpb4 from RNA polymerase II is important for yeast functionality
L Duek, O Barkai, R Elran, I Adawi, M Choder - PloS one, 2018 - journals.plos.org
Rpb4 is an RNA polymerase II (Pol II) subunit that binds Pol II transcripts co-transcriptionally,
accompanies them to the cytoplasm and modulates mRNA export, translation and decay by …
accompanies them to the cytoplasm and modulates mRNA export, translation and decay by …
The need for systems tools in the practice of clinical medicine
Humanity is currently facing an unprecedented chronic disease burden. Healthcare needs
have significantly shifted from treating acute to treating chronic conditions. Chronic diseases …
have significantly shifted from treating acute to treating chronic conditions. Chronic diseases …