[HTML][HTML] Cartilage homeostasis and osteoarthritis
Healthy limb joints are important for maintaining health and attaining longevity.
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …
[HTML][HTML] The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression
YA Rim, Y Nam, JH Ju - International journal of molecular sciences, 2020 - mdpi.com
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the
adult population. OA is primarily caused by trauma induced by an external force or by age …
adult population. OA is primarily caused by trauma induced by an external force or by age …
SOX9 and the many facets of its regulation in the chondrocyte lineage
V Lefebvre, M Dvir-Ginzberg - Connective tissue research, 2017 - Taylor & Francis
ABSTRACT SOX9 is a pivotal transcription factor in developing and adult cartilage. Its gene
is expressed from the multipotent skeletal progenitor stage and is active throughout …
is expressed from the multipotent skeletal progenitor stage and is active throughout …
Fibroblast growth factor signaling in skeletal development and disease
DM Ornitz, PJ Marie - Genes & development, 2015 - genesdev.cshlp.org
Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate
skeletal development. FGF signaling regulates development of the limb bud and formation of …
skeletal development. FGF signaling regulates development of the limb bud and formation of …
The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis
CF Liu, V Lefebvre - Nucleic acids research, 2015 - academic.oup.com
SOX9 is a transcriptional activator required for chondrogenesis, and SOX5 and SOX6 are
closely related DNA-binding proteins that critically enhance its function. We use here …
closely related DNA-binding proteins that critically enhance its function. We use here …
Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes
SOX9 plays an important role in chondrocyte differentiation and, in the developing axial
skeleton, maintains the notochord and the demarcation of intervertebral disc compartments …
skeleton, maintains the notochord and the demarcation of intervertebral disc compartments …
[HTML][HTML] Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte
Sox9 encodes an essential transcriptional regulator of chondrocyte specification and
differentiation. When Sox9 nuclear activity was compared with markers of chromatin …
differentiation. When Sox9 nuclear activity was compared with markers of chromatin …
Neural crest development: insights from the zebrafish
M Rocha, N Singh, K Ahsan, A Beiriger… - Developmental …, 2020 - Wiley Online Library
Our understanding of the neural crest, a key vertebrate innovation, is built upon studies of
multiple model organisms. Early research on neural crest cells (NCCs) was dominated by …
multiple model organisms. Early research on neural crest cells (NCCs) was dominated by …
[HTML][HTML] Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte degeneration in traumatic osteoarthritis by targeting ELF3
X Chen, Y Shi, P Xue, X Ma, J Li, J Zhang - Arthritis research & therapy, 2020 - Springer
Background Emerging evidence suggests that microRNAs (miRs) are associated with the
progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p derived …
progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p derived …
[HTML][HTML] Cell-intrinsic Aryl Hydrocarbon Receptor signalling is required for the resolution of injury-induced colonic stem cells
The aryl hydrocarbon receptor (AHR) is an environmental sensor that integrates microbial
and dietary cues to influence physiological processes within the intestinal …
and dietary cues to influence physiological processes within the intestinal …