Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …

The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises
potassium chloride cotransporters (KCCs, eg KCC1, KCC2, KCC3, and KCC4)-mediated …

The TMEM16A channel regulates vascular function by controlling artery tone and capillary
diameter as well as vessel formation and histology. Preclinical and clinical investigations are …

Stroke is one of the major culprits responsible for morbidity and mortality worldwide, and the
currently available pharmacological strategies to combat this global disease are scanty …

Chloride is a key anion involved in cellular physiology by regulating its homeostasis and
rheostatic processes. Changes in cellular Cl− concentration result in differential regulation of …

Rett syndrome is a neurodevelopmental disorder caused by loss-of-function mutations in the
methyl-CpG binding protein-2 (MeCP2) gene that is characterized by epilepsy, intellectual …

Background Glioma is one of the most common malignant brain tumors. It has a high rate of
progression and a poor prognosis, and effective biomarkers still need to be identified. The …

The overt expression of circadian rhythms is a manifestation of the suprachiasmatic nucleus
(SCN). This integrated complex function based on the transcriptional/translational feedback …

GABAAR is one of the most significant drug targets in the treatment of neuropsychiatric
disorders such as epilepsy, insomnia, anxiety, as well as anesthesia in surgical operations …