Therapeutic potential of NAD-boosting molecules: the in vivo evidence
L Rajman, K Chwalek, DA Sinclair - Cell metabolism, 2018 - cell.com
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …
well known for its role in redox reactions. More recently, it has emerged as a signaling …
Migration of dendritic cell subsets and their precursors
GJ Randolph, J Ochando… - Annu. Rev. Immunol …, 2008 - annualreviews.org
The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a
consequence of their localization within tissues and their specialized capacity for …
consequence of their localization within tissues and their specialized capacity for …
TRPM2 Functions as a Lysosomal Ca2+-Release Channel in β Cells
I Lange, S Yamamoto, S Partida-Sanchez, Y Mori… - Science …, 2009 - science.org
TRPM2 is a Ca2+-permeable cation channel that is specifically activated by adenosine
diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca2+ influx …
diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca2+ influx …
CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential
Our interest in chronic lymphocytic leukemia (CLL) derives primarily from the exploitation of
human diseases as strategic models for defining the in vivo biological roles of CD38. Using …
human diseases as strategic models for defining the in vivo biological roles of CD38. Using …
In the eye of the neutrophil swarm—navigation signals that bring neutrophils together in inflamed and infected tissues
T Lämmermann - Journal of Leucocyte Biology, 2016 - academic.oup.com
Neutrophils are sentinel cells that express in higher vertebrates> 30 chemokine and
chemoattractant receptors to sense and quickly react to tissue damage signals. Intravital …
chemoattractant receptors to sense and quickly react to tissue damage signals. Intravital …
The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation
H Knowles, Y Li, AL Perraud - Immunologic research, 2013 - Springer
TRPM2 (transient receptor potential melastatin 2) is the unique fusion of a Ca 2+-permeable
pore with an enzymatic domain that binds the NAD+-metabolite ADP-ribose (ADPR) …
pore with an enzymatic domain that binds the NAD+-metabolite ADP-ribose (ADPR) …
[HTML][HTML] Compartmentation of NAD+-dependent signalling
F Koch-Nolte, S Fischer, F Haag, M Ziegler - FEBS letters, 2011 - Elsevier
NAD+ plays central roles in energy metabolism as redox carrier. Recent research has
identified important signalling functions of NAD+ that involve its consumption. Although …
identified important signalling functions of NAD+ that involve its consumption. Although …
A lectin receptor kinase as a potential sensor for extracellular nicotinamide adenine dinucleotide in Arabidopsis thaliana
Nicotinamide adenine dinucleotide (NAD+) participates in intracellular and extracellular
signaling events unrelated to metabolism. In animals, purinergic receptors are required for …
signaling events unrelated to metabolism. In animals, purinergic receptors are required for …
Enhancing NAD+ salvage pathway reverts the toxicity of primary astrocytes expressing amyotrophic lateral sclerosis-linked mutant superoxide dismutase 1 (SOD1)
Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-
dependent signaling pathways. Although the redox reactions are critical for efficient …
dependent signaling pathways. Although the redox reactions are critical for efficient …
Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction
S Partida-Sanchez, A Gasser, R Fliegert… - The Journal of …, 2007 - journals.aai.org
The ectoenzyme CD38 catalyzes the production of cyclic ADP-ribose (cADPR) and ADP-
ribose (ADPR) from its substrate, NAD+. Both products of the CD38 enzyme reaction play …
ribose (ADPR) from its substrate, NAD+. Both products of the CD38 enzyme reaction play …