Use of poly lactic-co-glycolic acid nano and micro particles in the delivery of drugs modulating different phases of inflammation

C Puricelli, CL Gigliotti, I Stoppa, S Sacchetti… - Pharmaceutics, 2023 - mdpi.com
Chronic inflammation contributes to the pathogenesis of many diseases, including
apparently unrelated conditions such as metabolic disorders, cardiovascular diseases …

Harms with placebo in trials of biological therapies and small molecules as maintenance therapy in inflammatory bowel disease: a systematic review and meta …

B Gros, J Blackwell, J Segal, CJ Black… - The Lancet …, 2024 - thelancet.com
Background Randomised placebo-controlled trials for the induction of inflammatory bowel
disease (IBD) remission involve potential harms to those receiving placebo. Whether these …

Therapeutic effects of genistein in experimentally induced ulcerative colitis in rats via affecting mitochondrial biogenesis

TS Alharbi, ZS Alshammari, ZN Alanzi… - Molecular and Cellular …, 2024 - Springer
Ulcerative colitis (UC) is an inflammatory bowel disease that affects the mucosa of the colon,
resulting in severe inflammation and ulcers. Genistein is a polyphenolic isoflavone present …

Extraintestinal cancers in inflammatory bowel disease: A literature review

A Massano, L Bertin, F Zingone, A Buda, P Visaggi… - Cancers, 2023 - mdpi.com
Simple Summary Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory
bowel diseases that affect the gut and extraintestinal organs. Preliminary evidence has …

Pharmacological therapy in inflammatory bowel diseases: a narrative review of the past 90 years

M Imbrizi, F Magro, CSR Coy - Pharmaceuticals, 2023 - mdpi.com
Inflammatory Bowel Diseases had their first peak in incidence in countries in North America,
Europe, and Oceania and are currently experiencing a new acceleration in incidence …

Mycobacterium avium ssp. paratuberculosis and Crohn's Disease—Diagnostic Microbiological Investigations Can Inform New Therapeutic Approaches

JM Aitken, JE Aitken, G Agrawal - Antibiotics, 2024 - mdpi.com
Mycobacterium avium ssp. paratuberculosis (MAP) is the cause of Johne's disease (JD),
which is a chronic infectious gastrointestinal disease of ruminants and is often fatal. In …

Immunity in digestive diseases: new drugs for inflammatory bowel disease treatment—insights from Phase II and III trials

S Massironi, F Furfaro, S Bencardino, M Allocca… - Journal of …, 2024 - Springer
Background Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and
ulcerative colitis (UC), continues to challenge treatment paradigms. Advancements in …

Network pharmacology mechanisms and experimental verification of licorice in the treatment of ulcerative colitis

J Kong, Q Xiang, W Ge, Y Wang, F Xu, G Shi - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Licorice is widely used in the treatment of ulcerative colitis
(UC) and has good antioxidant and anti-inflammatory effects, but its specific active …

Ca2+-Dependent Processes of Innate Immunity in IBD

F Palestra, G Memoli, A Ventrici, M Trocchia… - Cells, 2024 - mdpi.com
IBD is an uncontrolled inflammatory condition of the gastrointestinal tract, which mainly
manifests in two forms: ulcerative colitis (UC) and Crohn's disease (CD). The pathogenesis …

Novel Therapeutic Approaches in Inflammatory Bowel Diseases

G Pallio - Biomedicines, 2023 - mdpi.com
Inflammatory bowel diseases (IBDs) encompass ulcerative colitis (UC) and Crohn's disease
(CD), both of which are inflammatory ailments affecting the gastrointestinal tract. Despite …