Non-motor features of Parkinson disease

AHV Schapira, KR Chaudhuri, P Jenner - Nature Reviews …, 2017 - nature.com
Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

Parkinson's disease dementia: a neural networks perspective

J Gratwicke, M Jahanshahi, T Foltynie - Brain, 2015 - academic.oup.com
In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …

Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson's disease

K Irmady, CR Hale, R Qadri, J Fak, S Simelane… - Nature …, 2023 - nature.com
The ability to use blood to predict the outcomes of Parkinson's disease, including disease
progression and cognitive and motor complications, would be of significant clinical value …

Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease

GM Petzinger, BE Fisher, S McEwen, JA Beeler… - The Lancet …, 2013 - thelancet.com
Exercise interventions in individuals with Parkinson's disease incorporate goal-based motor
skill training to engage cognitive circuitry important in motor learning. With this exercise …

Caffeine and Parkinson's disease: multiple benefits and emerging mechanisms

X Ren, JF Chen - Frontiers in Neuroscience, 2020 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder,
characterized by dopaminergic neurodegeneration, motor impairment and non-motor …

Inverted-U–shaped dopamine actions on human working memory and cognitive control

R Cools, M D'Esposito - Biological psychiatry, 2011 - Elsevier
Brain dopamine (DA) has long been implicated in cognitive control processes, including
working memory. However, the precise role of DA in cognition is not well-understood, partly …

Executive dysfunction in P arkinson's disease: A review

G Dirnberger, M Jahanshahi - Journal of neuropsychology, 2013 - Wiley Online Library
Executive dysfunction can be present from the early stages of P arkinson's disease (PD). It is
characterized by deficits in internal control of attention, set shifting, planning, inhibitory …

Cognitive impairment in Parkinson's disease: the dual syndrome hypothesis

AA Kehagia, RA Barker, TW Robbins - Neurodegenerative diseases, 2012 - karger.com
Research into the heterogeneous nature of cognitive impairment documented in patients
with Parkinson's disease (PD) has focused on disentangling deficits that vary between …

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

KR Chaudhuri, AHV Schapira - The Lancet Neurology, 2009 - thelancet.com
Several studies, including work from the Parkinson's disease (PD) non-motor group and
others, have established that the non-motor symptoms of PD are common, occur across all …

Neuroanatomical and neurochemical bases of theory of mind

A Abu-Akel, S Shamay-Tsoory - Neuropsychologia, 2011 - Elsevier
This paper presents a novel neurobiological model of theory of mind (ToM) that incorporates
both neuroanatomical and neurochemical levels of specificity. Within this model, cortical and …