MYCN impact on high-risk neuroblastoma: from diagnosis and prognosis to targeted treatment
D Bartolucci, L Montemurro, S Raieli, S Lampis… - Cancers, 2022 - mdpi.com
Simple Summary Neuroblastoma is one of the most diffuse and the deadliest cancer in
children. While many advances have been made in the last few decades to improve patients' …
children. While many advances have been made in the last few decades to improve patients' …
[HTML][HTML] Accelerating drug development for neuroblastoma: summary of the second neuroblastoma drug development strategy forum from innovative therapies for …
Only one class of targeted agents (anti-GD2 antibodies) has been incorporated into front-
line therapy for neuroblastoma since the 1980s. The Neuroblastoma New Drug …
line therapy for neuroblastoma since the 1980s. The Neuroblastoma New Drug …
c-MYC-induced long noncoding RNA MEG3 aggravates kidney ischemia–reperfusion injury through activating mitophagy by upregulation of RTKN to trigger the Wnt/β …
D Liu, Y Liu, X Zheng, N Liu - Cell death & disease, 2021 - nature.com
Abstract Ischemia–reperfusion injury (IRI)-induced acute kidney injury (AKI) is a life-
threatening disease. The activation of mitophagy was previously identified to play an …
threatening disease. The activation of mitophagy was previously identified to play an …
[HTML][HTML] The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting
TRAP1, the mitochondrial component of the Hsp90 family of molecular chaperones, displays
important bioenergetic and proteostatic functions. In tumor cells, TRAP1 contributes to shape …
important bioenergetic and proteostatic functions. In tumor cells, TRAP1 contributes to shape …
Precision anti-cancer medicines by oligonucleotide therapeutics in clinical research targeting undruggable proteins and non-coding RNAs
Cancer incidence and mortality continue to increase, while the conventional
chemotherapeutic drugs confer limited efficacy and relevant toxic side effects. Novel …
chemotherapeutic drugs confer limited efficacy and relevant toxic side effects. Novel …
MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma
S Raieli, D Di Renzo, S Lampis, C Amadesi… - Frontiers in …, 2021 - frontiersin.org
A wide range of malignancies presents MYCN amplification (MNA) or dysregulation. MYCN
is associated with poor prognosis and its over-expression leads to several dysregulations …
is associated with poor prognosis and its over-expression leads to several dysregulations …
Emerging therapeutic targets for neuroblastoma
N Aravindan, T Herman, S Aravindan - Expert opinion on …, 2020 - Taylor & Francis
Introduction Neuroblastoma (NB) is the prime cancer of infancy, and accounts for 9% of
pediatric cancer deaths. While children diagnosed with clinically stable NB experience a …
pediatric cancer deaths. While children diagnosed with clinically stable NB experience a …
Suppression of oxidative phosphorylation and IDH2 sensitizes colorectal cancer to a naphthalimide derivative and mitoxantrone
C Ge, Y Wang, Y Feng, S Wang, K Zhang, X Xu… - Cancer letters, 2021 - Elsevier
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Oxidative
phosphorylation (OXPHOS) has attracted a considerable attention in CRC. It is of great …
phosphorylation (OXPHOS) has attracted a considerable attention in CRC. It is of great …
[HTML][HTML] SP1-induced HOXD-AS1 promotes malignant progression of cholangiocarcinoma by regulating miR-520c-3p/MYCN
J Li, X Jiang, Z Li, L Huang, D Ji, L Yu, Y Zhou… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
The purpose of this article is to explore the function and mechanism of HOXD-AS1 in
cholangiocarcinoma. TCGA, StarBase and JASPAR were applied to predict the differential …
cholangiocarcinoma. TCGA, StarBase and JASPAR were applied to predict the differential …
Perisciatic Nerve Dexmedetomidine Alleviates Spinal Oxidative Stress and Improves Peripheral Mitochondrial Dynamic Equilibrium in a Neuropathic Pain Mouse …
Y Mu, Y Mei, Y Chen, Y Li, D Zhu, J Cui… - Disease Markers, 2022 - Wiley Online Library
Neuropathic pain (NPP) is a debilitating clinical condition that presently has few effective
treatments. NPP is caused by uncontrolled central oxidative stress and inflammation …
treatments. NPP is caused by uncontrolled central oxidative stress and inflammation …