The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism …

E Tissino, A Gaglio, A Nicolò, F Pozzo, T Bittolo… - Leukemia, 2024 - nature.com
In chronic lymphocytic leukemia (CLL), survival of neoplastic cells depends on
microenvironmental signals at lymphoid sites where the crosstalk between the integrin VLA …

Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death

ME Mantione, M Meloni, I Sana, J Bordini… - Cell Death & …, 2024 - nature.com
Microenvironmental signals strongly influence chronic lymphocytic leukemia (CLL) cells
through the activation of distinct membrane receptors, such as B-cell receptors, and …

Toll‐like receptor 9 signaling in chronic lymphocytic leukemia cell lines

M Meloni, I Sana, ME Mantione, M Riba… - FEBS Open …, 2023 - Wiley Online Library
Chronic lymphocytic leukemia (CLL) is a prototypic neoplasia in which malignant cells
strongly depend on microenvironmental stimulations in the lymphoid tissues where they …

[HTML][HTML] 慢性淋巴细胞白血病中B 细胞受体同型模式的生物学特征和临床意义

邱彤璐, 李建勇, 夏奕 - Chinese Journal of Hematology, 2024 - pmc.ncbi.nlm.nih.gov
慢性淋巴细胞白血病(CLL) 是西方成人最常见的白血病, 尽管CLL 在亚洲人种中发病率偏低,
但随着人口老龄化, CLL 发病率在我国呈上升趋势. CLL 细胞与微环境的交互中, B …

EXPRESSION OF IMMUNOGLOBULIN LIGHT CHAIN GENES IN STEREOTYPED CASES FROM UKRAINIAN COHORT OF CHRONIC LYMPHOCYTIC LEUKEMIA …

I Abramenko, N Bilous, Z Martina… - Experimental …, 2024 - exp-oncology.com.ua
Background. Analysis of immunoglobulin heavy chain gene (IGHV) rearrangements
expressed in chronic lymphocytic leukemia (CLL) cells has provided insights into the B-cell …

[PDF][PDF] Λειτουργική μελέτη των κλωνοτυπικών ανοσοσφαιρινών σε ασθενείς με Β λεμφώματα

ΕΠ Κοτρώνη - 2023 - ir.lib.uth.gr
Περίληψη Η λειτουργική μελέτη των ανοσοσφαιρινών αποτελεί ένα από τα σημαντικότερα
ερευνητικά βήματα για τη βαθύτερη κατανόηση της οντογένεσης των Β λεμφωμάτων. Με …

[PDF][PDF] Modelling the ability of targeted drugs and immunotherapy to modulate anti-tumour T cell activity in Chronic Lymphocytic Leukaemia

D Papazoglou - 2022 - kclpure.kcl.ac.uk
PDX Patient-derived xenograft PD-1 Programmed cell death protein 1 PD-L1 Programmed
cell death-Ligand 1 PD-L2 Programmed cell death-Ligand 2 PDGF Platelet-derived growth …

Caratterizzazione degli specifici effetti off-target degli inibitori della Bruton tirosin-chinasi sull'immunità innata antifungina in pazienti con patologie linfoproliferative B …

V Nasillo - 2021 - iris.unimore.it
Invasive fungal diseases (IFDs) represent an important cause of morbidity and mortality in
patients affected by lymphoproliferative diseases. In the recent years, the introduction of new …

[PDF][PDF] Somatic hypermutation in CLL: From bench to bedside

S Nathany, A Mehta, H Diwan, D Kumar… - Journal of Current …, 2022 - researchgate.net
Chronic lymphocytic leukemia (CLL) is a molecularly heterogeneous disease with a clonal
proliferation of B lymphocytes. Immunoglobulin (Ig) sequence analysis is widely employed …

[PDF][PDF] Mutacijski status gena IGHV in stereotipnost B-celičnega receptorja pri slovenskih bolnikih s kronično limfocitno levkemijo

S Milanović - Zbornik povzetkov april 2024, 2023 - zhs.si
Kronično limfocitno levkemijo (KLL) uvrščamo med limfatične novotvorbe zrelih limfocitov B
ali ne-Hodgkinove limfome. Predstavlja najpogostejšo obliko levkemije v zahodnem svetu …