The normative modeling framework for computational psychiatry

S Rutherford, SM Kia, T Wolfers, C Fraza, M Zabihi… - Nature protocols, 2022 - nature.com
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …

Conceptualizing mental disorders as deviations from normative functioning

AF Marquand, SM Kia, M Zabihi, T Wolfers… - Molecular …, 2019 - nature.com
Normative models are a class of emerging statistical techniques useful for understanding the
heterogeneous biology underlying psychiatric disorders at the level of the individual …

[HTML][HTML] Flood susceptibility modelling using advanced ensemble machine learning models

ARMT Islam, S Talukdar, S Mahato, S Kundu… - Geoscience …, 2021 - Elsevier
Floods are one of nature's most destructive disasters because of the immense damage to
land, buildings, and human fatalities. It is difficult to forecast the areas that are vulnerable to …

Mental health and well-being of university students: A bibliometric mapping of the literature

D Hernández-Torrano, L Ibrayeva, J Sparks… - Frontiers in …, 2020 - frontiersin.org
The purpose of this study is to map the literature on mental health and well-being of
university students using metadata extracted from 5,561 journal articles indexed in the Web …

Research domain criteria (RDoC): progress and potential

BN Cuthbert - Current Directions in Psychological Science, 2022 - journals.sagepub.com
The National Institute of Mental Health (NIMH) addressed in its 2008 Strategic Plan an
emerging concern that the current diagnostic system was hampering translational research …

Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models

T Wolfers, NT Doan, T Kaufmann, D Alnæs… - JAMA …, 2018 - jamanetwork.com
Importance Schizophrenia and bipolar disorder are severe and complex brain disorders
characterized by substantial clinical and biological heterogeneity. However, case-control …

Brain disorders? Not really: Why network structures block reductionism in psychopathology research

D Borsboom, AOJ Cramer, A Kalis - Behavioral and Brain Sciences, 2019 - cambridge.org
In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

Brain disorders? precisely

TR Insel, BN Cuthbert - Science, 2015 - science.org
Mental disorders represent a public health challenge of staggering proportions. In the most
recent Global Burden of Disease study, mental and substance abuse disorders constitute …

A conceptual framework for the neurobiological study of resilience

R Kalisch, MB Müller, O Tüscher - Behavioral and brain sciences, 2015 - cambridge.org
The well-replicated observation that many people maintain mental health despite exposure
to severe psychological or physical adversity has ignited interest in the mechanisms that …

[HTML][HTML] Understanding heterogeneity in clinical cohorts using normative models: beyond case-control studies

AF Marquand, I Rezek, J Buitelaar, CF Beckmann - Biological psychiatry, 2016 - Elsevier
Background Despite many successes, the case-control approach is problematic in
biomedical science. It introduces an artificial symmetry whereby all clinical groups (eg …