Mechanistic insights into the multiple functions of niacinamide: Therapeutic implications and cosmeceutical applications in functional skincare products

C Marques, F Hadjab, A Porcello, K Lourenço… - Antioxidants, 2024 - mdpi.com
Niacinamide (or nicotinamide) is a small-molecule hydrosoluble vitamin with essential
metabolic functions in mammalian cells. Niacinamide has become a key functional …

Drug repositioning: playing dirty to kill pain

LFS Bastos, MM Coelho - CNS drugs, 2014 - Springer
The number of approved new molecular entity drugs has been decreasing as the
pharmaceutical company investment in research and development is increasing. As we face …

Development of novel cocrystal-based active food packaging by a quality by design approach

F Bianchi, F Fornari, N Riboni, C Spadini, CS Cabassi… - Food Chemistry, 2021 - Elsevier
A way to reduce food waste is related to the increase of the shelf-life of food as a result of
improving the package type. An innovative active food packaging material based on …

Comparative spectral (FT-IR, FT-Raman, UV) investigations, HOMO–LUMO, NBO and in-silico docking analysis of Nikethamide, niazid and 2-Mercaptonicotinic acid

G Karpagakalyaani, JD Magdaline… - Journal of Molecular …, 2022 - Elsevier
Abstract The FT-IR and FT-Raman spectra of N, N-Diethylnicotinamide (ENA), Nicotinic
Hydrazide (NHD) and 2-Mercaptonicotinic acid (MNA) were recorded and analyzed …

Highly polymorphous nicotinamide and isonicotinamide: solution versus melt crystallization

N Fellah, CJ Zhang, C Chen, CT Hu, B Kahr… - Crystal Growth & …, 2021 - ACS Publications
The crystallization of nicotinamide (NA) and its constitutional isomer, isonicotinamide (INA),
is compared. NA formed eight polymorphs from the melt and two from solution, whereas INA …

Crystallization of Metastable Isonicotinamide Polymorphs and Prevention of Concomitant Crystallization by Additives

A Semjonova, A Be̅rziṇš - Crystal Growth & Design, 2023 - ACS Publications
Concomitant crystallization of polymorphs is a major problem for the pharmaceutical
industry, and in general, a better understanding of this phenomenon is necessary to ensure …

Potential effects of the combination of nicotinamide, vitamin B2 and vitamin C on oxidative-mediated hepatotoxicity induced by thioacetamide

SAE Bashandy, H Ebaid… - Lipids in health and …, 2018 - Springer
Background The liver disease is one of the most important traditional public health problems
in Egypt. Oxidative stress is attributed to such pathological condition that further contributes …

Dehydration kinetics and mechanism of the stable isonicotinamide hydrate revealed by terahertz spectroscopy and DFT calculation

B Yang, Y Li, J Lei, M Cai, ZG Hu, Y Shen… - International Journal of …, 2023 - Elsevier
The dehydration behavior of pharmaceutical hydrates has a great influence on its
physiochemical properties such as stability, dissolution rate and bioavailability. However …

Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF-α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP …

AV Braga, SOAM Costa, FF Rodrigues, ISF Melo… - …, 2020 - Springer
Some B vitamins exhibit activities in models of nociceptive pain, inflammatory pain, and
neuropathic pain induced by nerve lesions and also in certain painful conditions in humans …

Modulating the dissolution and mechanical properties of resveratrol by cocrystallization

H He, Q Zhang, M Li, JR Wang, X Mei - Crystal Growth & Design, 2017 - ACS Publications
Resveratrol (RSV), a dietary polyphenol found in red wine, has renewed interest in recent
years due to a broad range of in vitro evidence that indicate cardioprotective effects. Herein …