In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

Microglial involvement in Alzheimer's disease (AD) pathology has emerged as a risk-
determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it …

Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether
ensembles play a functional role in behavior. Some ensemble neurons have pattern …

The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …

Microglia constitute a highly specialized network of tissue-resident immune cells that is
important for the control of tissue homeostasis and the resolution of diseases of the CNS …

Carbon nanomaterials are a class of low-dimensional materials that have aroused a great
deal of interest in the past 30 years since the spectacular debut of fullerene, the first member …

An increasingly powerful approach for studying brain circuits relies on targeting genetically
encoded sensors and effectors to specific cell types. However, current approaches for this …

Optical imaging through the intact mouse skull is challenging because of skull-induced
aberrations and scattering. We found that three-photon excitation provided improved optical …

To date, brain imaging has largely relied on X-ray computed tomography and magnetic
resonance angiography, with their limited spatial resolution and long scanning times …