On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …

SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

The new type of coronavirus (COVID-19), SARS-CoV-2 originated from Wuhan, China and
has led to a worldwide pandemic. COVID-19 is a novel emerging infectious disease caused …

To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …

Growing clinical evidence has implicated complement as a pivotal driver of COVID-19
immunopathology. Deregulated complement activation may fuel cytokine-driven hyper …

Background Complement pathway inhibition may provide benefit for severe acute
respiratory illnesses caused by viral infections such as COVID-19. We present results from a …

The complement system consists of a network of plasma and membrane proteins that
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …

Objectives Uncontrolled thromboinflammation plays an important role in the pathogenesis of
coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated …

Respiratory failure and acute kidney injury (AKI) are associated with high mortality in SARS-
CoV-2-associated Coronavirus disease 2019 (COVID-19). These manifestations are linked …

Abstract Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory
infection that is caused by the severe acute respiratory syndrome coronavirus 2. Although …