RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
[HTML][HTML] The p38 pathway: from biology to cancer therapy
A Martínez-Limón, M Joaquin, M Caballero… - International journal of …, 2020 - mdpi.com
The p38 MAPK pathway is well known for its role in transducing stress signals from the
environment. Many key players and regulatory mechanisms of this signaling cascade have …
environment. Many key players and regulatory mechanisms of this signaling cascade have …
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours
in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive …
in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive …
[HTML][HTML] MAP kinase pathways
DK Morrison - Cold Spring Harbor perspectives in …, 2012 - cshperspectives.cshlp.org
MAP Kinase Pathways Cold Spring Harbor Perspectives in Biology Skip to main page content
HOME ABOUT SUBJECT COLLECTIONS ARCHIVE SUBSCRIBE ADVERTISE ALERTS …
HOME ABOUT SUBJECT COLLECTIONS ARCHIVE SUBSCRIBE ADVERTISE ALERTS …
Mechanisms and functions of p38 MAPK signalling
A Cuadrado, AR Nebreda - Biochemical journal, 2010 - portlandpress.com
The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …
interpret a wide range of external signals and respond appropriately by generating a …
[HTML][HTML] The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation
The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …
Signal integration by JNK and p38 MAPK pathways in cancer development
EF Wagner, ÁR Nebreda - Nature Reviews Cancer, 2009 - nature.com
Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …
members function in a cell context-specific and cell type-specific manner to integrate signals …
Controlling gene expression in response to stress
E De Nadal, G Ammerer, F Posas - Nature Reviews Genetics, 2011 - nature.com
Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival.
Cellular adaptation mechanisms include modification of certain aspects of cell physiology …
Cellular adaptation mechanisms include modification of certain aspects of cell physiology …
Physiology of cell volume regulation in vertebrates
EK Hoffmann, IH Lambert… - Physiological …, 2009 - journals.physiology.org
The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …