Abstract Polyploid Giant Cancer Cells (PGCC) are increasingly being recognized as drivers
of cancer recurrence. Therapy stress promotes the formation of these cells, which upon …

Cholesterol-laden macrophages are recognized as a major contributor to atherosclerosis.
However, recent evidence indicates that vascular smooth muscle cells (VSMC) that …

Endothelial ABCA1 expression protects against atherosclerosis and this atheroprotective
effect is partially attributed to enhancing apoAI-mediated cholesterol efflux. ABCA1 is a …

Recent evidence suggests that the majority of cholesterol‐laden cells found in
atherosclerotic lesions are vascular smooth muscle cells (VSMC) that have …

ABCA1 and ABCG1 are two ABC-transporters well-recognized to promote the efflux of
cholesterol to apoAI and HDL, respectively. As these two ABC-transporters are critical to …

Atherosclerosis is driven by intimal arterial macrophages accumulating cholesterol.
Atherosclerosis also predominantly occurs in areas consisting of proinflammatory arterial …

Background The binding of low-density lipoprotein (LDL) to proteoglycans (PGs) in the
extracellular matrix (ECM) of the arterial intima is a key initial step in the development of …

Trypanosoma brucei causes African trypanosomiasis in humans. Infection with T. brucei
elicits a potent pro-inflammatory immune response within infected human hosts, and this …

Obesity is a condition caused by surplus adipose tissue and is a risk factor for several diet-
related diseases. Obesity is a global epidemic that has also been challenging to treat …

Atherosclerosis is caused by cholesterol accumulation within arteries. The intima is where
atherosclerotic plaque accumulates and where lipid-laden foam cells reside. Intimal foam …