Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Cholesterol is essential for neuronal physiology, both during development and in the adult
life: as a major component of cell membranes and precursor of steroid hormones, it …

A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …

Free radicals originate from both exogenous environmental sources and as by-products of
the respiratory chain and cellular oxygen metabolism. Sustained accumulation of free …

Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone
proteins that play a critical role in mitigating and preventing protein aggregation under stress …

Nuclear clusterin (nCLU) is an ionizing radiation (IR)-inducible protein that binds Ku70, and
triggers apoptosis when overexpressed in MCF-7 cells. We demonstrate that endogenous …

Clusterin, also known as apolipoprotein J, is a versatile chaperone molecule which contains
several amphipathic and coiled-coil α-helices, typical characteristics of small heat shock …

Clusterin is an extracellular chaperone present in all disease‐associated extracellular
amyloid deposits, but its roles in amyloid formation and protein deposition in vivo are poorly …