Normal eating behaviour is coordinated by the tightly regulated balance between intestinal
and extra-intestinal homeostatic and hedonic mechanisms. By contrast, food addiction is a …

The role of serotonin in food intake has been studied for decades. Food intake is mainly
regulated by two brain circuitries:(i) the homeostatic circuitry, which matches energy intake …

The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its “incretin effect”
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …

Olanzapine is an effective antipsychotic drug but since it causes significant weight gain, it is
not well tolerated by psychosis patients. The prebiotic, B-GOS®, attenuates metabolic …

ABSTRACT Introduction: Anorexia nervosa (AN), bulimia nervosa (BN) and binge eating
disorder (BED) are the primary eating disorders (EDs). The only psychopharmacological …

Aim This study aims to review the current evidence regarding appetite problem in cancer
patients, mainly focusing on pathophysiology, diagnosis, and treatment. Introduction …

Psilocybin and other serotonergic psychedelics have re-emerged as therapeutics for
neuropsychiatric disorders, including addiction. Psilocybin induces long-lasting effects on …

Defects in brain energy metabolism and proteopathic stress are implicated in age-related
degenerative neuronopathies, exemplified by Alzheimer's disease (AD) and Parkinson's …

Incretin-potentiated glucose-stimulated insulin secretion (GSIS) is critical to maintaining
euglycemia, of which GLP-1 receptor (GLP-1R) on β-cells plays an indispensable role …

Central and peripheral serotonin (5-hydroxytryptamine, 5-HT) regulate feeding signals for
energy metabolism. Disruption of central 5-HT signaling via 5-HT2C receptors (5-HT2CRs) …