The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

Depression has become one of the most severe psychiatric disorders and endangers the
health of living beings all over the world. In order to explore the molecular mechanism that …

Background Accumulating evidence suggests that commensal bacteria consumption has the
potential to have a positive impact on stress‐related psychiatric disorders. However, the …

The forced swim test (FST) is one of the most commonly used animal models for assessing
antidepressant-like behavior. This protocol details using the FST in rats, which takes place …

A markedly reduced interest or pleasure in activities previously considered pleasurable is a
main symptom in mood disorder and psychosis and is often present in other psychiatric …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Adverse early life events can induce long-lasting changes in physiology and behavior. We
found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone …

Stress is a major risk factor in the onset of several neuropsychiatric disorders including
anxiety and depression. Although several studies have shown that social isolation stress …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Our gut harbours trillions of microorganisms essential for the maintenance of homeostasis
and host physiology in health and disease. In the last decade, there has been a growing …