Metabolism reprogramming is critical for both cancer progression and effective immune
responses in the tumor microenvironment. Amino acid metabolism in different cells and their …

Cancer cells must rewire cellular metabolism to satisfy the demands of growth and
proliferation. Although many of the metabolic alterations are largely similar to those in …

Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and
glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian …

Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …

Cancer cells exhibit an abnormal amino acid metabolism and a dependence on specific
amino acids, which might provide potential targets for treating cancer patients. In this study …

Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid
asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly …

Amino acids play central roles in cancer progression beyond their function as building
blocks for protein synthesis. Thus, targeting amino acid acquisition and utilization has been …

Genome-wide DNA methylation patterns are frequently deregulated in cancer. There is
considerable interest in targeting the methylation machinery in tumor cells using nucleoside …

Asparagine synthetase (ASNS) catalyzes the conversion of aspartate and glutamine to
asparagine and glutamate in an ATP-dependent reaction. The enzyme is ubiquitous in its …