The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …

Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

To identify the molecular mechanisms and novel therapeutic targets of late-onset
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …

DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or
chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based …

Micro-electrode arrays (MEAs) are increasingly used to characterize neuronal network
activity of human induced pluripotent stem cell (hiPSC)-derived neurons. Despite their gain …

Human neurons engineered from induced pluripotent stem cells (iPSCs) through
neurogenin 2 (NGN2) overexpression are widely used to study neuronal differentiation …

Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being
responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic …

Dravet syndrome is a severe epileptic encephalopathy, characterized by (febrile) seizures,
behavioural problems and developmental delay. Eighty per cent of patients with Dravet …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with
various neurological complications. Although the mechanism is not fully understood, several …

Kleefstra syndrome (KS) is a neurodevelopmental disorder caused by mutations in the
histone methyltransferase EHMT1. To study the impact of decreased EHMT1 function in …