The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Three and a half years after the pandemic outbreak, now that WHO has formally declared
that the emergency is over, COVID-19 is still a significant global issue. Here, we focus on …

Mechanisms underpinning the dysfunctional immune response in severe acute respiratory
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …

Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in
intestinal pathological conditions,–. However, the players and mechanisms that underlie …

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can
inform our understanding of the underlying biological mechanisms that influence adverse …

Abstract Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease
that has caused millions of deaths, where comprehensive understanding of disease …

Background We previously reported that impaired type I IFN activity, due to inborn errors of
TLR3-and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type …

Genome-wide association studies (GWASs) are a research approach used to identify
genetic variants associated with common diseases, like COVID-19. The lead genetic …

Uncovering how host metal (loid) s mediate the immune response against invading
pathogens is critical for better understanding the pathogenesis mechanism of infectious …

SARS‐CoV‐2 may directly and indirectly damage lung tissue and other host organs, but
there are few system‐wide, untargeted studies of these effects on the human body. Here, we …