Despite advancements in standardizing the criteria for acute kidney injury (AKI), its definition
remains based on changes in serum creatinine and urinary output that do not specifically …

Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

Background This systematic review and meta-analysis explored the relationship between
vancomycin (VCM) monitoring strategies and VCM effectiveness and safety. Methods We …

Background: Recent studies have identified the combination of vancomycin with piperacillin-
tazobactam (VPT) to be associated with increased nephrotoxicity. Multiple, large cohort …

Vancomycin is the most frequently used antibiotic, accounting for up to 35% of hospitalized
patients with infection, because of its optimal bactericidal effectiveness and relatively low …

Acute kidney injury is a common complication in critically ill patients with sepsis and/or
septic shock. Further, some essential antimicrobial treatment drugs are themselves …

Vancomycin is a recommended therapy in multiple national guidelines. Despite the common
use, there is a poor understanding of the mechanistic drivers and potential modifiers of …

Background Acute kidney injury is a major complication of vancomycin treatment, especially
when it is co-administered with other nephrotoxins. Objectives This meta-analysis aims to …

A host of novel renal biomarkers have been developed over the past few decades which
have enhanced monitoring of renal disease and drug-induced kidney injury in both …

Clinical studies have reported additive nephrotoxicity associated with the combination of
vancomycin (VAN) and piperacillin-tazobactam (TZP). This study assessed differences in …