Modulation of DNA double-strand break repair as a strategy to improve precise genome editing
U Ray, SC Raghavan - Oncogene, 2020 - nature.com
In the present day, it is possible to incorporate targeted mutations or replace a gene using
genome editing techniques such as customisable CRISPR/Cas9 system. Although induction …
genome editing techniques such as customisable CRISPR/Cas9 system. Although induction …
Understanding the DNA double-strand break repair and its therapeutic implications
U Ray, SC Raghavan - DNA repair, 2021 - Elsevier
Repair of DNA double-strand breaks (DSBs) and its regulation are tightly integrated inside
cells. Homologous recombination, nonhomologous end joining and microhomology …
cells. Homologous recombination, nonhomologous end joining and microhomology …
Identification and characterization of mercaptopyrimidine‐based small molecules as inhibitors of nonhomologous DNA end joining
Mercaptopyrimidine derivatives are heterocyclic compounds with potent biological activities
including antiproliferative, antibacterial, and anti‐inflammatory properties. The present study …
including antiproliferative, antibacterial, and anti‐inflammatory properties. The present study …
Identification and characterization of novel SCR7‐based small‐molecule inhibitor of DNA end‐joining, SCR130 and its relevance in cancer therapeutics
Targeting DNA repair with small‐molecule inhibitors is an attractive strategy for cancer
therapy. Majority of DNA double‐strand breaks in mammalian cells are repaired through …
therapy. Majority of DNA double‐strand breaks in mammalian cells are repaired through …
SCR7, an inhibitor of NHEJ can sensitize tumor cells to ionization radiation
Nonhomologous end joining (NHEJ), one of the major DNA double‐strand break repair
pathways, plays a significant role in cancer cell proliferation and resistance to radio and …
pathways, plays a significant role in cancer cell proliferation and resistance to radio and …
SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining
Background DNA double‐strand breaks (DSBs) are harmful to the cell as it could lead to
genomic instability and cell death when left unrepaired. Homologous recombination and …
genomic instability and cell death when left unrepaired. Homologous recombination and …
Small-molecule enhancers of CRISPR-induced homology-directed repair in gene therapy: A medicinal chemist's perspective
ABC Lee, MH Tan, CLL Chai - Drug Discovery Today, 2022 - Elsevier
Highlights•Small molecules can tip the balance in favor of the HDR pathway over the NHEJ
pathway.•Cell cycle inhibitors and HDAC inhibitors can indirectly enhance precise …
pathway.•Cell cycle inhibitors and HDAC inhibitors can indirectly enhance precise …
Inhibitors of DNA double-strand break repair at the crossroads of cancer therapy and genome editing
U Ray, SC Raghavan - Biochemical Pharmacology, 2020 - Elsevier
Conventional cancer treatment modalities such as radiation and chemotherapy, cause
cancer cell death by inducing DNA damage, particularly DNA strand breaks. Over the years …
cancer cell death by inducing DNA damage, particularly DNA strand breaks. Over the years …
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Nonhomologous end joining (NHEJ), one of the major DNA double‐strand break repair
pathways, plays a significant role in cancer cell proliferation and resistance to radio and …
pathways, plays a significant role in cancer cell proliferation and resistance to radio and …
Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability
ER Maddi, SC Raghavan… - … Engineering, Design and …, 2021 - academic.oup.com
Studies have shown that Lig4 syndrome mutations in DNA ligase IV (LigIV) are
compromised in its function with residual level of double strand break ligation activity in vivo …
compromised in its function with residual level of double strand break ligation activity in vivo …